In vivo neurochemistry of primary focal hand dystonia: a magnetic resonance spectroscopic neurometabolite profiling study at 3T

Mov Disord. 2010 Dec 15;25(16):2800-8. doi: 10.1002/mds.23306.

Abstract

The neurochemical basis of dystonia is unknown. The purpose of this study was to assess the differences of the inhibitory neurotransmitter, gamma amino butyric acid (GABA), in the sensorimotor cortex and the basal ganglia using magnetic resonance spectroscopy with optimized GABA sensitivity. Twenty-two patients with focal hand dystonia and 22 healthy controls were studied. No significant differences in GABA were observed between the groups in either the sensorimotor cortex or in the basal ganglia.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Basal Ganglia / metabolism*
  • Basal Ganglia / pathology
  • Botulinum Toxins, Type A / therapeutic use
  • Cerebral Cortex / metabolism*
  • Cerebral Cortex / pathology
  • Dystonic Disorders / metabolism*
  • Dystonic Disorders / pathology
  • Dystonic Disorders / therapy
  • Humans
  • Magnetic Resonance Spectroscopy
  • Middle Aged
  • Neuromuscular Agents / therapeutic use
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Neuromuscular Agents
  • gamma-Aminobutyric Acid
  • Botulinum Toxins, Type A