Synthesis of novel 1-[(2,6-dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes

Huanan Hu; Changhua Ge; Lisheng Ding; Anjiang Zhang

doi:10.3390/molecules15107472

Synthesis of novel 1-[(2,6-dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes

Molecules. 2010 Oct 25;15(10):7472-81. doi: 10.3390/molecules15107472.

Authors

Huanan Hu¹, Changhua Ge, Lisheng Ding, Anjiang Zhang

Affiliation

¹ College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China. hhn12192000@yahoo.com.cn

Abstract

A series of novel 1-[(2,6-dichloro-4-trifluoromethyl)phenyl]-3-aryl-¹H-pyrazole-4-carbaldehydes were synthesized using the Vilsmeier-Haack reagent. The structures of all the title compounds have been confirmed by elemental analysis, ¹H-NMR and ¹³C-NMR and in addition, the structure of intermediate 5b was investigated by X-ray crystallography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemical synthesis*
Aldehydes / chemistry
Crystallography, X-Ray
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry

Substances

Aldehydes
Pyrazoles