Developmental biology: a DOR connecting growth and clocks

Curr Biol. 2010 Oct 26;20(20):R884-6. doi: 10.1016/j.cub.2010.09.034.

Abstract

DOR, a nuclear receptor co-activator conserved from flies to humans, provides a molecular connection between ecdysone and insulin signaling, two important pathways controlling developmental timing and growth, respectively.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism*
  • DNA-Binding Proteins / physiology
  • Drosophila Proteins / metabolism*
  • Drosophila Proteins / physiology
  • Drosophila melanogaster / growth & development*
  • Ecdysone / metabolism*
  • Homeostasis / physiology*
  • Insulin / metabolism*
  • Models, Biological
  • Receptors, Steroid / metabolism
  • Signal Transduction / physiology*

Substances

  • DNA-Binding Proteins
  • DOR protein, Drosophila
  • Drosophila Proteins
  • Insulin
  • Receptors, Steroid
  • ecdysone receptor
  • Ecdysone