The microbicidal and cytoregulatory roles of NADPH oxidases

Hung-Chi Yang; Mei-Ling Cheng; Hung-Yao Ho; Daniel Tsun-Yee Chiu

doi:10.1016/j.micinf.2010.10.008

The microbicidal and cytoregulatory roles of NADPH oxidases

Microbes Infect. 2011 Feb;13(2):109-20. doi: 10.1016/j.micinf.2010.10.008. Epub 2010 Nov 4.

Authors

Hung-Chi Yang¹, Mei-Ling Cheng, Hung-Yao Ho, Daniel Tsun-Yee Chiu

Affiliation

¹ Department of Medical Biotechnology and Laboratory Sciences, Chang-Gung University, Kwei-san, Tao-Yuan, Taiwan.

PMID: 20971207
DOI: 10.1016/j.micinf.2010.10.008

Abstract

Despite their prominent microbicidal roles, NADPH oxidases (NOXs) have been recently found to regulate a wide variety of physiological activities. Through generation of reactive oxygen species (ROS), NOXs actively participate in cellular activities, including NET formation, inflammasome activation and wound sensing. The microbicidal and cytoregulatory roles of NOXs are contrasted in this review.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Anti-Infective Agents / metabolism*
Gene Expression Regulation
Humans
Infections / enzymology
Inflammation / enzymology
NADPH Oxidases / metabolism*
Reactive Oxygen Species / metabolism
Signal Transduction

Substances

Anti-Infective Agents
Reactive Oxygen Species
NADPH Oxidases