Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity

Ramaiyan Manikannan; Ramaiyan Venkatesan; Shanmugam Muthusubramanian; Perumal Yogeeswari; Dharmarajan Sriram

doi:10.1016/j.bmcl.2010.09.137

Pyrazole derivatives from azines of substituted phenacyl aryl/cyclohexyl sulfides and their antimycobacterial activity

Bioorg Med Chem Lett. 2010 Dec 1;20(23):6920-4. doi: 10.1016/j.bmcl.2010.09.137. Epub 2010 Oct 7.

Authors

Ramaiyan Manikannan¹, Ramaiyan Venkatesan, Shanmugam Muthusubramanian, Perumal Yogeeswari, Dharmarajan Sriram

Affiliation

¹ Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India.

PMID: 20970331
DOI: 10.1016/j.bmcl.2010.09.137

Abstract

Azines derived from substituted phenacyl aryl/cyclohexyl sulfide on treatment with excess phosphorous oxychloride in N,N-dimethylformamide have been found to yield two isomeric pyrazoles in each case. A plausible mechanism has been suggested for the formation of the products. The antimycobacterial activity of the isomeric compounds has been tested against Mycobacterium tuberculosis (MTB).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology
Dimethylformamide
Formamides / chemistry
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Pyrazoles / chemistry
Pyrazoles / pharmacology*
Sulfides / chemistry
Sulfides / pharmacology*

Substances

Anti-Bacterial Agents
Antitubercular Agents
Formamides
Pyrazoles
Sulfides
Dimethylformamide