Usually, insulinomas are small sized, insulin secreting, benign tumors of the pancreas, and require surgical treatment. We report the case of a female patient, of 61 years old, with pancreatic insulinoma localized in the junction between the head and the istm of the pancreas, of 1,4 cm in size, which induced hypoglycemia due to endogenous insulin hypersecretion. The tumor was removed by laparoscopic enucleation in March 2009. In the postoperative period, the blood glucose level came back to normal.