Simulations of lipid vesicle rupture induced by an adjacent supported lipid bilayer patch

Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):632-6. doi: 10.1016/j.colsurfb.2010.09.023. Epub 2010 Oct 20.

Abstract

Using a simple phenomenological model of a lipid bilayer and a surface, simulations were performed to study the bilayer-induced vesicle rupture probability as a vesicle adsorbs adjacently to a bilayer patch already adsorbed on the surface. The vesicle rupture probability was studied as a function of temperature, vesicle size, and surface-bilayer interaction strength. From the simulation data, estimates of the apparent activation energy for bilayer-induced vesicle rupture were calculated, both for different vesicle sizes and for different surface-bilayer interaction strengths.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Algorithms
  • Biophysics / methods
  • Computer Simulation
  • Lipid Bilayers / chemistry*
  • Lipids / chemistry*
  • Membrane Fluidity
  • Models, Theoretical
  • Monte Carlo Method
  • Stress, Mechanical
  • Surface Properties
  • Temperature

Substances

  • Lipid Bilayers
  • Lipids