Clopidogrel pharmacogenomics: next steps: a clinical algorithm, gene-gene interactions, and an elusive outcomes trial

JACC Cardiovasc Interv. 2010 Oct;3(10):995-1000. doi: 10.1016/j.jcin.2010.08.012.

Abstract

Clopidogrel pharmacogenomics has received significant attention since a black box warning was announced by the Food and Drug Administration in March. This has left clinicians in a difficult situation where many questions remain unanswered. In this brief viewpoint article, we ask some pointed questions of our own and outline the pathway that needs to be taken for clinical translation to occur.

Publication types

  • Review

MeSH terms

  • Algorithms*
  • Biotransformation / genetics
  • Clinical Trials as Topic*
  • Clopidogrel
  • Drug Labeling
  • Evidence-Based Medicine
  • Genetic Testing*
  • Genotype
  • Humans
  • Pharmacogenetics*
  • Phenotype
  • Platelet Aggregation Inhibitors / administration & dosage*
  • Platelet Aggregation Inhibitors / adverse effects
  • Platelet Aggregation Inhibitors / pharmacokinetics
  • Precision Medicine
  • Risk Assessment
  • Ticlopidine / administration & dosage
  • Ticlopidine / adverse effects
  • Ticlopidine / analogs & derivatives*
  • Ticlopidine / pharmacokinetics
  • United States
  • United States Food and Drug Administration

Substances

  • Platelet Aggregation Inhibitors
  • Clopidogrel
  • Ticlopidine