We present here our experience with a 34-year-old woman living in the province of Cuneo in northwest Italy. The patient had no prior allergic disease history and in the place of bite by Aedes albopictus, she sustained significant reactions (ecchymosis), along with fever and localized lymphadenopathy. Thirty days later, the bites were still visible, characterized by cutaneous thickening and localized paresthesia. This clinical case represents a hypersensitive reaction and can be considered the first documented case of Skeeter syndrome in Italy.