Evolving therapies to treat retroglossal and base-of-tongue obstruction in pediatric obstructive sleep apnea

Arch Otolaryngol Head Neck Surg. 2010 Oct;136(10):983-7. doi: 10.1001/archoto.2010.178.

Abstract

Objective: To describe our experience treating retroglossal and base-of-tongue collapse in children and young adults with obstructive sleep apnea using combined genioglossus advancement (Repose THS; MedtronicENT, Jacksonville, Florida) and radiofrequency ablation of the tongue base.

Design: Retrospective institutional review board-approved analysis of 31 operations.

Setting: Tertiary pediatric medical center.

Patients: Thirty-one patients with a mean age of 11.5 years (age range, 3.1-23.0 years).

Interventions: Combined genioglossus advancement and radiofrequency ablation.

Main outcome measures: Preoperative and postoperative polysomnographic data were evaluated for each patient. Success of surgery was determined using the criteria of a postoperative apnea-hypopnea index of 5 or fewer events per hour, without evidence of hypoxemia (oxygen saturation as measured by pulse oximetry), and without prolonged hypercarbia (end-tidal carbon dioxide).

Results: Thirty-one patients who underwent genioglossus advancement were analyzed. Nineteen (61%) had Down syndrome. The overall success rate was 61% (19 of 31) (58% [12 of 19] success among patients with Down syndrome and 66% [7 of 12] success among patients without Down syndrome). Overall, the mean apnea-hypopnea index improved from 14.1 to 6.4 events per hour (P < .001); the mean nadir oxygen saturation as measured by pulse oximetry during apnea improved from 87.4% to 90.9% (P = .07).

Conclusions: Pediatric obstructive sleep apnea refractory to adenotonsillectomy that is due to retroglossal and base-of-tongue collapse remains difficult to treat. However, most patients in this analysis benefited from combined genioglossus advancement and radiofrequency ablation.

MeSH terms

  • Adolescent
  • Catheter Ablation*
  • Child
  • Child, Preschool
  • Down Syndrome / epidemiology
  • Female
  • Humans
  • Male
  • Oral Surgical Procedures*
  • Oximetry
  • Oxygen / blood
  • Polysomnography
  • Retrospective Studies
  • Severity of Illness Index
  • Sleep Apnea, Obstructive / surgery*
  • Tongue / surgery*
  • Tonsillectomy
  • Young Adult

Substances

  • Oxygen