Emergence of Klebsiella pneumoniae coproducing KPC-2 and 16S rRNA methylase ArmA in Poland

Antimicrob Agents Chemother. 2011 Jan;55(1):443-6. doi: 10.1128/AAC.00386-10. Epub 2010 Oct 18.

Abstract

A Klebsiella pneumoniae epidemic strain that coproduced carbapenemase KPC-2 (K. pneumoniae carbapenemase 2) and 16S rRNA methylase ArmA has emerged in Poland. Four nonduplicate isolates from patients in a hospital in Warsaw, Poland, were found to carry the bla(KPC-2) and armA genes on ca. 50-kb and 90-kb plasmids, respectively. Tn4401 with a 100-bp deletion in the variable region was detected in all the isolates. XbaI pulsed-field gel electrophoresis (PFGE) revealed 93.2% similarity of the isolates. All the isolates were resistant to carbapenems and 4,6-disubstituted 2-deoxystreptamines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / pharmacology
  • Hexosamines / chemistry
  • Hexosamines / pharmacology
  • Humans
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Methyltransferases / metabolism*
  • Poland
  • RNA, Ribosomal, 16S / metabolism*
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Hexosamines
  • RNA, Ribosomal, 16S
  • Methyltransferases
  • rRNA (adenosine-O-2'-)methyltransferase
  • beta-lactamase KPC-2
  • beta-Lactamases
  • 2-deoxystreptamine