Sebestenoids A-D, BACE1 inhibitors from Cordia sebestena

Phytochemistry. 2010 Dec;71(17-18):2168-73. doi: 10.1016/j.phytochem.2010.09.008. Epub 2010 Oct 15.

Abstract

Bioassay-guided fractionation of an extract prepared from the fruits of Cordia sebestena led to the isolation of sebestenoids A-D (1-4). Their structures were elucidated on the basis of extensive NMR experiments and mass spectroscopic measurements. Compounds 1-4 exhibited moderate inhibition of the aspartic protease BACE1.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aspartic Acid Proteases / antagonists & inhibitors*
  • Cordia / chemistry*
  • Fruit / chemistry
  • Hawaii
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Phenylpropionates / chemistry
  • Phenylpropionates / isolation & purification*
  • Phenylpropionates / pharmacology*

Substances

  • Phenylpropionates
  • sebestenoid C
  • sebestenoid D
  • Aspartic Acid Proteases