Abstract
Bioassay-guided fractionation of an extract prepared from the fruits of Cordia sebestena led to the isolation of sebestenoids A-D (1-4). Their structures were elucidated on the basis of extensive NMR experiments and mass spectroscopic measurements. Compounds 1-4 exhibited moderate inhibition of the aspartic protease BACE1.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aspartic Acid Proteases / antagonists & inhibitors*
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Cordia / chemistry*
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Fruit / chemistry
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Hawaii
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phenylpropionates / chemistry
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Phenylpropionates / isolation & purification*
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Phenylpropionates / pharmacology*
Substances
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Phenylpropionates
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sebestenoid C
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sebestenoid D
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Aspartic Acid Proteases