Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei

Guang Wen Sun; Yunn-Hwen Gan

doi:10.1016/j.tim.2010.09.002

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei

Trends Microbiol. 2010 Dec;18(12):561-8. doi: 10.1016/j.tim.2010.09.002. Epub 2010 Oct 15.

Authors

Guang Wen Sun¹, Yunn-Hwen Gan

Affiliation

¹ Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8, Medical Drive, Singapore 117597.

PMID: 20951592
DOI: 10.1016/j.tim.2010.09.002

Abstract

Burkholderia pseudomallei is a highly versatile pathogen capable of infecting many species of animals and plants. It is the causative agent of melioidosis, a medically important infectious disease in humans with a wide spectrum of disease manifestations. Its versatility as a pathogen is reflected in its huge 7.2Mb genome and the many virulence mechanisms it possesses, including three different type III secretion systems (T3SSs). Recent elucidation of the regulatory network of T3SS3 and the characterization of several T3SS proteins have enabled us to construct a model of the B. pseudomallei T3SS3 apparatus and evaluate the role it plays in disease pathogenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bacterial Secretion Systems*
Burkholderia pseudomallei / metabolism*
Burkholderia pseudomallei / pathogenicity
Humans

Substances

Bacterial Secretion Systems