Clotting factors and eicosanoids protect against nematode infections

J Innate Immun. 2011;3(1):65-70. doi: 10.1159/000320634. Epub 2010 Oct 16.

Abstract

We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together, our results confirm the conserved nature of the immune function of clot formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Coagulation / immunology
  • Blood Coagulation Factors / metabolism*
  • Blood Coagulation Factors / pharmacology
  • Drosophila melanogaster / immunology*
  • Drosophila melanogaster / microbiology
  • Drosophila melanogaster / parasitology
  • Eicosanoids / metabolism*
  • Eicosanoids / pharmacology
  • Hemolymph / metabolism
  • Immunity, Innate
  • Photorhabdus / pathogenicity*
  • Rhabditida / microbiology
  • Rhabditida / pathogenicity*
  • Symbiosis
  • Transglutaminases / metabolism*
  • Transglutaminases / pharmacology

Substances

  • Blood Coagulation Factors
  • Eicosanoids
  • Transglutaminases