Abstract
We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together, our results confirm the conserved nature of the immune function of clot formation.
Copyright © 2010 S. Karger AG, Basel.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blood Coagulation / immunology
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Blood Coagulation Factors / metabolism*
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Blood Coagulation Factors / pharmacology
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Drosophila melanogaster / immunology*
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Drosophila melanogaster / microbiology
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Drosophila melanogaster / parasitology
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Eicosanoids / metabolism*
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Eicosanoids / pharmacology
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Hemolymph / metabolism
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Immunity, Innate
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Photorhabdus / pathogenicity*
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Rhabditida / microbiology
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Rhabditida / pathogenicity*
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Symbiosis
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Transglutaminases / metabolism*
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Transglutaminases / pharmacology
Substances
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Blood Coagulation Factors
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Eicosanoids
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Transglutaminases