Emerging disease-modifying oral therapies for multiple sclerosis

J Neuroimmunol. 2011 Feb;231(1-2):15-22. doi: 10.1016/j.jneuroim.2010.09.016. Epub 2010 Oct 13.

Abstract

Although therapy for multiple sclerosis (MS) has changed substantially over the past few decades, introducing immunomodulatory drugs into everyday clinical practice, it is still not satisfactory enough in halting the disease progression and increasing disability. Moreover, its injection-based administration leads to suboptimal adherence, even further reducing the potential treatment benefits. Emerging disease-modifying oral agents for MS are therefore warranted. In this paper advances in the novel oral therapeutic approaches to MS treatment are reviewed.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • Clinical Trials as Topic / methods
  • Clinical Trials as Topic / trends
  • Drug Discovery / trends*
  • Fingolimod Hydrochloride
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Immunosuppressive Agents / therapeutic use
  • Multiple Sclerosis / drug therapy*
  • Multiple Sclerosis / immunology
  • Propylene Glycols / administration & dosage
  • Propylene Glycols / therapeutic use
  • Sphingosine / administration & dosage
  • Sphingosine / analogs & derivatives
  • Sphingosine / therapeutic use

Substances

  • Immunosuppressive Agents
  • Propylene Glycols
  • Fingolimod Hydrochloride
  • Sphingosine