Eighty percent of all spontaneous coronary artery dissections occur in women. A third of these occur in pregnancy or post-partum period and a variation in hormonal levels is thought to play an etiologic role. It has been suggested that the menstrual period, a low-estrogen state, may be associated with spontaneous coronary artery dissections. We report a case of menstruation-associated spontaneous coronary artery dissection and review the available literature.