Automatic formation of hypotheses on the relationships between structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens HK44

Folia Microbiol (Praha). 2010 Sep;55(5):411-7. doi: 10.1007/s12223-010-0069-7. Epub 2010 Oct 13.

Abstract

Seven hypotheses on relationships between the structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens were formulated using GUHA (General Unary Hypotheses Automaton) on a training set of 37 compounds. Prediction of bioluminescence response of 12 new naphthalene analogs was successful in 69 % cases and resulted in rejection of single hypothesis. The results demonstrate applicability of GUHA in structure-activity research, especially for qualitative data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques
  • Genes, Reporter*
  • Green Fluorescent Proteins / genetics
  • Green Fluorescent Proteins / metabolism
  • Luminescent Measurements
  • Naphthalenes / chemistry*
  • Naphthalenes / metabolism*
  • Naphthalenes / pharmacology
  • Pseudomonas fluorescens / drug effects*
  • Pseudomonas fluorescens / metabolism*
  • Structure-Activity Relationship

Substances

  • Naphthalenes
  • Green Fluorescent Proteins
  • naphthalene