Three new water-soluble alkaloids from the leaves of Suregada glomerulata (Blume) Baill

Ren-Yi Yan; Hong-Qing Wang; Chao Liu; Ruo-Yun Chen; De-Quan Yu

doi:10.1016/j.fitote.2010.10.004

Three new water-soluble alkaloids from the leaves of Suregada glomerulata (Blume) Baill

Fitoterapia. 2011 Mar;82(2):247-50. doi: 10.1016/j.fitote.2010.10.004. Epub 2010 Oct 19.

Authors

Ren-Yi Yan¹, Hong-Qing Wang, Chao Liu, Ruo-Yun Chen, De-Quan Yu

Affiliation

¹ Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xiannongtan Street, Beijing, 100050, People's Republic of China.

PMID: 20940031
DOI: 10.1016/j.fitote.2010.10.004

Abstract

Three new water-soluble alkaloids (1-3) together with twelve known compounds (4-15) have been isolated from the water extract of leaves of Suregada glomerulata. Their structures were determined by spectroscopic analysis and chemical method. Compounds 1-3 were evaluated for their in vitro inhibitory activity against α-glucosidase and HIV-1 replication. However, no significant activities were found.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

HIV-1
Molecular Structure
Plant Extracts / chemistry*
Plant Extracts / isolation & purification
Plant Leaves
Pyrans / chemistry
Pyrans / isolation & purification*
Pyrrolidines / chemistry
Pyrrolidines / isolation & purification*
Suregada / chemistry*
alpha-Glucosidases / metabolism

Substances

2alpha-carboxymethyl-5alpha-dimethylamino-4alpha-hydroxytetrahydropyran
5beta-carboxymethyl-3alpha-hydroxy-2beta-hydroxymethyl-1,1-dimethylpyrrolidine
5beta-carboxymethyl-3alpha-hydroxy-2beta-hydroxymethyl-1-methylpyrrolidine
Plant Extracts
Pyrans
Pyrrolidines
alpha-Glucosidases