γ-Oxygenation of α,β-unsaturated esters by vinylogous O-nitroso Mukaiyama aldol reaction

Guo-Qiang Tian; Jiong Yang; Kellymar Rosa-Perez

doi:10.1021/ol1021433

γ-Oxygenation of α,β-unsaturated esters by vinylogous O-nitroso Mukaiyama aldol reaction

Org Lett. 2010 Nov 5;12(21):5072-4. doi: 10.1021/ol1021433.

Authors

Guo-Qiang Tian¹, Jiong Yang, Kellymar Rosa-Perez

Affiliation

¹ Department of Chemistry, Texas A&M University, College Station, Texas 77843-3255, United States.

PMID: 20936857
DOI: 10.1021/ol1021433

Abstract

A practical procedure has been developed for γ-oxygenation of α,β-unsaturated esters by a vinylogous O-nitroso Mukaiyama aldol reaction followed by a one-pot N-O bond heterolysis of the in situ generated γ-aminoxy-α,β-unsaturated esters.