Comparison of postprandial oleic acid, 9c,11t CLA and 10t,12c CLA oxidation in healthy moderately overweight subjects

Lipids. 2010 Nov;45(11):1047-51. doi: 10.1007/s11745-010-3480-6. Epub 2010 Oct 9.

Abstract

Few studies report the individual effect of 9c,11t- and 10t,12c-CLA on human energy metabolism. We compared the postprandial oxidative metabolism of 9c,11t- and 10t,12c-CLA and oleic acid (9c-18:1) in 22 healthy moderately overweight volunteers. After 24 weeks supplementation with 9c,11t-, 10t,12c-CLA or 9c-18:1 (3 g/day), subjects consumed a single oral bolus of the appropriate [1-(13)C]-labeled fatty acid. 8 h post-dose, cumulative oxidation was similar for 9c-18:1 and 10t,12c (P = 0.66), but significantly higher for 9c,11t (P < 0.01).

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Disease Progression
  • Double-Blind Method
  • Female
  • Health*
  • Humans
  • Isomerism
  • Linoleic Acids, Conjugated / administration & dosage
  • Linoleic Acids, Conjugated / chemistry
  • Linoleic Acids, Conjugated / metabolism
  • Linoleic Acids, Conjugated / pharmacokinetics
  • Lipid Metabolism / drug effects
  • Male
  • Middle Aged
  • Oleic Acid / administration & dosage
  • Oleic Acid / chemistry
  • Oleic Acid / metabolism*
  • Oleic Acid / pharmacokinetics
  • Overweight / metabolism*
  • Oxidation-Reduction
  • Placebos
  • Postprandial Period*

Substances

  • Linoleic Acids, Conjugated
  • Placebos
  • Oleic Acid