Identification of DysI, the immunity factor of the streptococcal bacteriocin dysgalacticin

Appl Environ Microbiol. 2010 Dec;76(23):7885-9. doi: 10.1128/AEM.01707-10. Epub 2010 Oct 8.

Abstract

DysI is identified as the protein that confers specific immunity to dysgalacticin, a plasmid-encoded streptococcal bacteriocin. dysI is transcribed as part of the copG-repB-dysI replication-associated operon. DysI appears to function at the membrane level to prevent the inhibitory effects of dysgalacticin on glucose transport, membrane integrity, and intracellular ATP content.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Anti-Bacterial Agents / antagonists & inhibitors
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Bacteriocins / antagonists & inhibitors*
  • Bacteriocins / biosynthesis
  • Bacteriocins / genetics
  • Bacteriocins / pharmacology*
  • Genes, Bacterial
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Operon
  • Plasmids
  • Streptococcus / drug effects*
  • Streptococcus / genetics
  • Streptococcus / metabolism*
  • Transcription, Genetic

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Bacteriocins