Abstract
DysI is identified as the protein that confers specific immunity to dysgalacticin, a plasmid-encoded streptococcal bacteriocin. dysI is transcribed as part of the copG-repB-dysI replication-associated operon. DysI appears to function at the membrane level to prevent the inhibitory effects of dysgalacticin on glucose transport, membrane integrity, and intracellular ATP content.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / antagonists & inhibitors
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Bacteriocins / antagonists & inhibitors*
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Bacteriocins / biosynthesis
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Bacteriocins / genetics
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Bacteriocins / pharmacology*
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Genes, Bacterial
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Operon
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Plasmids
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Streptococcus / drug effects*
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Streptococcus / genetics
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Streptococcus / metabolism*
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Transcription, Genetic
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Bacteriocins