Abstract
The concise and enantioselective synthesis of 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) has been accomplished in 11 steps from a known alcohol. The key step of the synthesis involves an asymmetric Rh-catalyzed cycloisomerization of ene-ynone, followed by an olefin isomerization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Prostaglandin D2 / analogs & derivatives*
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Prostaglandin D2 / chemical synthesis
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Prostaglandin D2 / chemistry
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Rhodium / chemistry
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Stereoisomerism
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Substrate Specificity
Substances
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15-deoxy-delta(12,14)-prostaglandin J2
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Rhodium
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Prostaglandin D2