Abstract
Selective difluorination, introducing a lactame moiety (instead of an amine) and a double bond in a trihydroxy-2-thiaquinolizidine derivative reverses the selectivity of the glycosidase inhibitor - a selective inhibitor for an α-glucosidase is altered into an excellent, competitive inhibitor for a β-galactosidase.
MeSH terms
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Pyridines / metabolism*
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Pyridines / pharmacology*
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Thiazines / chemical synthesis*
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Thiazines / chemistry
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Thiazines / metabolism*
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Thiazines / pharmacology*
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beta-Galactosidase / antagonists & inhibitors*
Substances
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Enzyme Inhibitors
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Pyridines
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Thiazines
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beta-Galactosidase