A new diarylheptanoid from the bark of Alnus japonica

J Asian Nat Prod Res. 2010 Oct;12(10):921-4. doi: 10.1080/10286020.2010.507196.

Abstract

A new diarylheptanoid, epihirsutanonol (1), was isolated from the bark of Alnus japonica, along with two known ones (2 and 3). Their structures were elucidated on the basis of extensive spectroscopic evidence. The new compound 1 showed significant hepatoprotective activity on the basis of t-butylhydroperoxide-induced hepatocyte injury in vitro assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alnus / chemistry*
  • Diarylheptanoids / chemistry
  • Diarylheptanoids / isolation & purification*
  • Diarylheptanoids / pharmacology
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Hepatocytes / drug effects*
  • Liver / drug effects
  • Liver Diseases / drug therapy
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Bark / chemistry
  • Wounds and Injuries / chemically induced
  • tert-Butylhydroperoxide / pharmacology

Substances

  • Diarylheptanoids
  • Drugs, Chinese Herbal
  • epihirsutanonol
  • tert-Butylhydroperoxide