Modular approach to functional hyaluronic acid hydrogels using orthogonal chemical reactions

Dmitri A Ossipov; Xia Yang; Oommen Varghese; Sujit Kootala; Jöns Hilborn

doi:10.1039/c0cc03055d

Modular approach to functional hyaluronic acid hydrogels using orthogonal chemical reactions

Chem Commun (Camb). 2010 Nov 28;46(44):8368-70. doi: 10.1039/c0cc03055d. Epub 2010 Oct 5.

Authors

Dmitri A Ossipov¹, Xia Yang, Oommen Varghese, Sujit Kootala, Jöns Hilborn

Affiliation

¹ Department of Material Chemistry, Uppsala University, Ångström Laboratory, SE-75121, Uppsala, Sweden. dmitri.ossipov@mkem.uu.se

PMID: 20922254
DOI: 10.1039/c0cc03055d

Abstract

A modular approach for the synthesis of hyaluronic acid hydrogels using orthogonal chemoselective reactions for subsequent enzymatic decomposition to nanoparticles is described.

MeSH terms

Animals
Hyaluronic Acid / chemistry*
Hydrazones / chemical synthesis
Hydrazones / chemistry
Hydrogels / chemistry*
Magnetic Resonance Spectroscopy
Mice
Microscopy, Fluorescence
NIH 3T3 Cells
Nanoparticles / chemistry

Substances

Hydrazones
Hydrogels
Hyaluronic Acid