Enantioselective Pd-catalyzed hydrogenation of fluorinated imines: facile access to chiral fluorinated amines

Org Lett. 2010 Nov 5;12(21):5075-7. doi: 10.1021/ol1020256.

Abstract

An enantioselective hydrogenation of simple fluorinated imines has been developed using Pd(OCOCF(3))(2)/(R)-Cl-MeO-BIPHEP as a catalyst, and up to 94% ee was achieved. This method provides an efficient route to enantioenriched fluorinated amines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Catalysis
  • Halogenation
  • Hydrogenation
  • Imines / chemistry*
  • Molecular Structure
  • Palladium / chemistry*
  • Stereoisomerism

Substances

  • Amines
  • Imines
  • Palladium