Abstract
The isolation and structural elucidation of a new Phyllanthus glycoside, phyllanthostatin 6 [7], was summarized. Phyllanthostatin 6 [7] was isolated from the roots of Phyllanthus acuminatus (Euphorbiaceae) and was found to inhibit (ED50 = 0.35 micrograms/ml) growth of the murine P-388 lymphocytic leukemia cell line. Two other new constituents were shown to be didesacetylphyllanthostatin 3 [9] and descinnamoylphyllanthocindiol [10]. Structure determinations were achieved employing hrfabms and 2D-nmr spectroscopy. Application of an hplc separation technique to the Phyllanthus glycosides and development of a new isolation procedure for the major antineoplastic constituent, phyllanthoside [1], are also described.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Benzofurans / chemistry
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Benzofurans / isolation & purification
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Benzofurans / pharmacology*
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Chromatography, High Pressure Liquid
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Leukemia P388 / drug therapy
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Mice
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Molecular Structure
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Plants / analysis
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Pyrans / isolation & purification
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Sesquiterpenes*
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Spectrum Analysis
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Spiro Compounds
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Benzofurans
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Glycosides
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Pyrans
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Sesquiterpenes
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Spiro Compounds
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phyllanthostatin 6
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didesacetylphyllanthostatin 3
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descinnanoylphyllanthocindiol
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phyllanthoside