Abstract
Aging is associated with profound changes in bone mass and body composition. Emerging evidence supports the hypothesis that alterations in mesenchymal stromal cell fate are a critical etiologic factor. In addition, time-keeping at the cellular level is affected as aging progresses, particularly in the adipocyte. In this Extra View we discuss the interactive role of three molecules, PPARγ, nocturnin and IGF-I in regulating stem cell fate in the marrow and the potential implications of this network for understanding cellular aging.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adipocytes / metabolism*
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Adipocytes / physiology
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Aging / physiology*
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Animals
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Bone and Bones / metabolism
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Bone and Bones / physiology
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Insulin-Like Growth Factor I / genetics
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Insulin-Like Growth Factor I / metabolism
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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PPAR gamma / genetics
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PPAR gamma / metabolism
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Stromal Cells / cytology
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Stromal Cells / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Nuclear Proteins
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PPAR gamma
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Transcription Factors
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nocturnin
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Insulin-Like Growth Factor I