In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids

Vet J. 2011 Sep;189(3):353-5. doi: 10.1016/j.tvjl.2010.09.001. Epub 2010 Oct 2.

Abstract

The in vitro effects of the ω-3 polyunsaturated fatty acids (PUFAs) eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) on phagocytosis and the extracellular respiratory burst in caprine monocytes were assessed. Blood monocytes incubated with increasing concentrations of EPA or DHA (25-200 μM) demonstrated increased phagocytosis compared to unexposed monocytes. Generation of reactive oxygen species (ROS) was not markedly affected in the presence of EPA and DHA, except at 200 μM, at which concentrations monocyte viability was also reduced.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Docosahexaenoic Acids / pharmacology*
  • Eicosapentaenoic Acid / pharmacology*
  • Goats / immunology*
  • Monocytes / immunology*
  • Monocytes / metabolism
  • Phagocytosis*
  • Reactive Oxygen Species / immunology*
  • Reactive Oxygen Species / metabolism
  • Respiratory Burst

Substances

  • Reactive Oxygen Species
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid