Abstract
Research on antifungal compounds from the durable wood from French Guiana Amazonian forest trees highlights the correlation between the activity of their extracts against wood-rotting fungi and human pathogens. The fractionation of an ethyl acetate extract of Sextonia rubra wood led to the isolation of rubrenolide (1) and rubrynolide (2). The potential of compounds 1 and 2 is described through the evaluation of their activity against 16 pathogenic fungi and their cytotoxicity toward NIH-3T3 mammalian fibroblast cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetals / chemistry
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Acetals / isolation & purification*
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Acetals / pharmacology*
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Alkenes / chemistry
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Alkenes / isolation & purification*
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Alkenes / pharmacology*
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Alkynes / chemistry
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Alkynes / isolation & purification*
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Alkynes / pharmacology*
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology*
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Basidiomycota / chemistry*
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French Guiana
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Lauraceae / microbiology
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Mice
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Microbial Sensitivity Tests
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Molecular Structure
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NIH 3T3 Cells
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Plant Stems / chemistry
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Polyporaceae / chemistry*
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Trees / microbiology*
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Wood / microbiology
Substances
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Acetals
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Alkenes
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Alkynes
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Antifungal Agents
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rubrenolide
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rubrynolide