Endocytic receptor for pro-coagulant factor VIII: relevance to inhibitor formation

Thromb Haemost. 2010 Dec;104(6):1093-8. doi: 10.1160/TH10-05-0294. Epub 2010 Sep 30.

Abstract

The immunogenicity of therapeutic factor VIII (FVIII) in patients with haemophilia A remains a critical issue in patient management. This review describes the immunological processes involved in the activation of the immune system against FVIII, with a particular focus on the role of endocytic receptors for the recognition of FVIII by antigen-presenting cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibodies / blood*
  • Antigen-Presenting Cells / immunology*
  • Antigen-Presenting Cells / metabolism
  • Blood Coagulation*
  • CD4-Positive T-Lymphocytes / immunology
  • Coagulants / administration & dosage
  • Coagulants / immunology*
  • Coagulants / metabolism
  • Endocytosis*
  • Factor VIII / administration & dosage
  • Factor VIII / immunology*
  • Factor VIII / metabolism
  • Hemophilia A / blood
  • Hemophilia A / drug therapy*
  • Hemophilia A / immunology
  • Humans
  • Receptors, Cell Surface / metabolism*

Substances

  • Antibodies
  • Coagulants
  • Receptors, Cell Surface
  • Factor VIII