Pumilio turns on microRNA function

Nat Cell Biol. 2010 Oct;12(10):928-9. doi: 10.1038/ncb1010-928.

Abstract

Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3' untranslated region of p27 mRNA. This conformational change is required for efficient microRNA-mediated repression of this cell-cycle regulator in rapidly proliferating cells.

Publication types

  • Comment
  • News

MeSH terms

  • 3' Untranslated Regions / genetics
  • Animals
  • Cell Cycle
  • Cell Proliferation
  • Cyclin-Dependent Kinase Inhibitor p27 / genetics*
  • Gene Silencing
  • Humans
  • MicroRNAs / metabolism*
  • Nucleic Acid Conformation
  • RNA-Binding Proteins / metabolism*

Substances

  • 3' Untranslated Regions
  • MicroRNAs
  • RNA-Binding Proteins
  • Cyclin-Dependent Kinase Inhibitor p27