Abstract
Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3' untranslated region of p27 mRNA. This conformational change is required for efficient microRNA-mediated repression of this cell-cycle regulator in rapidly proliferating cells.
MeSH terms
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3' Untranslated Regions / genetics
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Animals
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Cell Cycle
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Cell Proliferation
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Cyclin-Dependent Kinase Inhibitor p27 / genetics*
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Gene Silencing
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Humans
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MicroRNAs / metabolism*
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Nucleic Acid Conformation
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RNA-Binding Proteins / metabolism*
Substances
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3' Untranslated Regions
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MicroRNAs
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RNA-Binding Proteins
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Cyclin-Dependent Kinase Inhibitor p27