Increased thromboxane production after whole body irradiation

Acta Biochim Pol. 1990;37(1):103-8.

Abstract

Irradiation causes an increase in serum and plasma level of thromboxane in rabbits and an increase in thromboxane synthesis in blood platelets stimulated by thrombin. Thromboxane release from thoracic aorta is also increased upon irradiation of animals. H2O2 which stimulates thromboxane release from thoracic control aorta is without effect in the irradiated one.

MeSH terms

  • Animals
  • Aorta, Thoracic / drug effects
  • Aorta, Thoracic / metabolism
  • Aorta, Thoracic / radiation effects*
  • Blood Platelets / metabolism
  • Blood Platelets / radiation effects*
  • Hydrogen Peroxide / pharmacology
  • In Vitro Techniques
  • Kinetics
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / metabolism
  • Muscle, Smooth, Vascular / radiation effects*
  • Rabbits
  • Rats
  • Rats, Inbred Strains
  • Reference Values
  • Thromboxane A2 / biosynthesis*
  • Thromboxane A2 / radiation effects
  • Thromboxane B2 / biosynthesis*
  • Thromboxane B2 / blood
  • Thromboxane B2 / radiation effects
  • Whole-Body Irradiation

Substances

  • Thromboxane B2
  • Thromboxane A2
  • Hydrogen Peroxide