As reflected in the literature, the use of dermal filler agents has increased substantially over the last decade. Consequently, these agents are more frequently encountered on histopathologic examination. A variety of dermal fillers can be readily identified histopathologically, and the accurate identification of these agents is a critical task for dermatopathologists. Furthermore, a basic understanding of the histological features of fillers has relevance to dermatologists and dermatologic surgeons. The identification of filler substances may have important diagnostic, medico-legal and medical management considerations. This concise review aims to provide a pragmatic approach to distinguishing the agents most frequently encountered in routine practice and in the literature.