Oxidative stress, inflammation, and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter

Toxicol Sci. 2010 Dec;118(2):574-85. doi: 10.1093/toxsci/kfq290. Epub 2010 Sep 23.

Abstract

Wood combustion is a significant source of ambient particulate matter (PM) in many regions of the world. Exposure occurs through inhalation or ingestion after deposition of wood smoke particulate matter (WSPM) on crops and food. We investigated effects of ambient PM and WSPM by intragastric or intratracheal exposure in terms of oxidative stress, inflammation, genotoxicity, and DNA repair after 24 h in liver and lung tissue of rats. Rats were exposed to WSPM from high or low oxygen combustion and ambient PM collected in areas with and without many operating wood stoves or carbon black (CB) at the dose of 0.64 mg/kg body weight. The levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine, 1,N(6)-etheno-2'-deoxyadenosine, and 1-N(2)-etheno-2'-deoxyguanosine (εdG) were significantly increased with 23% (95% confidence interval [CI]: 0.1-45%), 54% (95% CI:18-90%), and 73% (95% CI: 31-134%) in the liver of rats exposed orally to CB, respectively. Rats orally exposed to PM from the wood stove area and low oxygen combustion WSPM (LOWS) had 35% (95% CI: 0.1-71%) and 45% (95% CI: 10-82%) increased levels of εdG in the liver, respectively. No significant differences were observed for bulky DNA adducts. Increased gene expression of proinflammatory cytokines, heme oxygenase-1, and oxoguanine DNA glycosylase 1 was observed in the liver following intragastric exposure and in the lung following instillation in particular of LOWS. Exposure to LOWS also increased the proportion of neutrophils in BAL fluid. These results indicate that WSPM and CB exert the strongest effect in terms of oxidative stress-induced response, inflammation, and genotoxicity in the organ closest to the port of entry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Biomarkers / metabolism
  • Bronchoalveolar Lavage Fluid / cytology
  • Cell Count
  • Chemokine CCL2 / genetics
  • Chemokine CCL2 / metabolism
  • Chemokine CXCL2 / genetics
  • Chemokine CXCL2 / metabolism
  • Cytokines / genetics
  • Cytokines / metabolism
  • DNA Adducts / analysis
  • DNA Damage
  • DNA Glycosylases / genetics
  • DNA Glycosylases / metabolism
  • Gene Expression / drug effects
  • Heme Oxygenase-1 / genetics
  • Heme Oxygenase-1 / metabolism
  • Intubation, Intratracheal
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Oxidative Stress / drug effects*
  • Particulate Matter / toxicity*
  • Pneumonia / chemically induced*
  • Pneumonia / genetics
  • Pneumonia / metabolism
  • Rats
  • Rats, Inbred F344
  • Smoke / adverse effects*
  • Wood*

Substances

  • Biomarkers
  • Ccl2 protein, mouse
  • Chemokine CCL2
  • Chemokine CXCL2
  • Cxcl2 protein, mouse
  • Cytokines
  • DNA Adducts
  • Membrane Proteins
  • Particulate Matter
  • Smoke
  • Heme Oxygenase-1
  • Hmox1 protein, mouse
  • DNA Glycosylases
  • Ogg1 protein, mouse