A novel taxane 13-glucoside and other taxanes from the leaves of Taxus cuspidata

Planta Med. 2011 Feb;77(3):281-3. doi: 10.1055/s-0030-1250333. Epub 2010 Sep 22.

Abstract

Three new taxanes, 2 α,9 α,10 β-triacetoxy-13 α-( β-D-glucopyranosyloxy)taxa-4(20),11-dien-5 α-ol, 5 α,10 β,13 α-triacetoxytax-11-ene-2 α,7 β,9 α,20-tetraol, and 5 α,10 β,13 β-triacetoxy-2 α,7 β-dihydroxy-2(3→20) abeotaxa-4(20),11-dien-9-one, were isolated from the leaves of the Japanese yew, Taxus cuspidata. Compound 1 is the first example of a taxane with 13-glycosidic linkage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Molecular Structure
  • Plant Extracts* / chemistry
  • Plant Extracts* / isolation & purification
  • Plant Leaves
  • Taxoids / chemistry
  • Taxoids / isolation & purification*
  • Taxus / chemistry*

Substances

  • 2alpha,9alpha,10beta-triacetoxy-13alpha(beta-D-glucopyranosyloxy)taxa-4(20),11-dien-5alpha-ol
  • 5alpha,10beta,13alpha-triacetoxytax-11-ene-2alpha,7beta,9alpha,20-tetraol
  • 5alpha,10beta,13beta-triacetoxy-2 alpha,7beta-dihydroxy-2(3-20) abeotaxa-4(20),11-dien-9-one
  • Glucosides
  • Plant Extracts
  • Taxoids