Abstract
An efficient protocol for the construction of C-6-(hetero)aryl-substituted uridine phosphonate analogues utilizing an aerobic, ligand-free Suzuki-Miyaura cross-coupling reaction of a 6-iodo-precursor in aqueous media has been established. The method presents a modular approach toward the target compounds as demonstrated by the synthesis of a small library comprising 14 novel nucleoside phosphonates.
MeSH terms
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Alkenes / chemistry
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Boronic Acids / chemistry
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Carbon / chemistry*
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Hydrogenation
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Indicators and Reagents
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Ligands
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Magnetic Resonance Spectroscopy
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Models, Chemical*
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Organophosphonates / chemical synthesis*
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Organophosphonates / chemistry
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Oxidation-Reduction
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Oxygen / chemistry*
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Temperature
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Uridine / chemical synthesis*
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Uridine / chemistry
Substances
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Alkenes
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Boronic Acids
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Indicators and Reagents
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Ligands
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Organophosphonates
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Carbon
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Oxygen
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Uridine