Enantioselective conjugate addition of boronic acids to enones catalyzed by O-monoacyltartaric acids

Chem Commun (Camb). 2010 Nov 7;46(41):7799-800. doi: 10.1039/c0cc03076g. Epub 2010 Sep 20.

Abstract

We have found that O-monoacyltartaric acids catalyze asymmetric conjugate addition of boronic acids to enones with good enantioselectivity, and the 3,5-di(tert-butyl)benzoyl group provides the best results among the acyl groups examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Boronic Acids / chemistry*
  • Catalysis
  • Ketones / chemistry*
  • Stereoisomerism
  • Substrate Specificity
  • Tartrates / chemistry*

Substances

  • Alkenes
  • Boronic Acids
  • Ketones
  • Tartrates
  • tartaric acid