A novel electrochemiluminescence strategy for ultrasensitive DNA assay using luminol functionalized gold nanoparticles multi-labeling and amplification of gold nanoparticles and biotin-streptavidin system

Chem Commun (Camb). 2010 Oct 28;46(40):7560-2. doi: 10.1039/c0cc02356f. Epub 2010 Sep 17.

Abstract

Luminol functionalized gold nanoparticles were used as labels for electrochemiluminescence signal amplification and an ultrasensitive, highly selective, convenient, low cost DNA detection strategy was developed.

Publication types

  • Evaluation Study

MeSH terms

  • Base Sequence
  • Biosensing Techniques / economics
  • Biosensing Techniques / methods*
  • Biotin / chemistry
  • DNA / analysis*
  • Electrochemistry / economics
  • Electrochemistry / methods
  • Gold / chemistry*
  • Humans
  • Luminescent Measurements / economics
  • Luminescent Measurements / methods*
  • Luminol / chemistry*
  • Nanoparticles / chemistry*
  • Sensitivity and Specificity
  • Serum / chemistry
  • Streptavidin / chemistry

Substances

  • Luminol
  • Biotin
  • Gold
  • DNA
  • Streptavidin