Synthesis and antifungal activity of benzofuran-5-ols

Chung-Kyu Ryu; Ae Li Song; Jung Yoon Lee; Jung An Hong; Joo Hee Yoon; Aram Kim

doi:10.1016/j.bmcl.2010.08.129

Synthesis and antifungal activity of benzofuran-5-ols

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6777-80. doi: 10.1016/j.bmcl.2010.08.129. Epub 2010 Sep 28.

Authors

Chung-Kyu Ryu¹, Ae Li Song, Jung Yoon Lee, Jung An Hong, Joo Hee Yoon, Aram Kim

Affiliation

¹ College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@ewha.ac.kr

PMID: 20851600
DOI: 10.1016/j.bmcl.2010.08.129

Abstract

Benzofuran-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many benzofuran-5-ols showed good antifungal activity. The results suggest that benzofuran-5-ols would be promising antifungal agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / pharmacology*
Aspergillus / drug effects
Benzofurans / chemical synthesis*
Benzofurans / pharmacology*
Candida / drug effects
Cryptococcus neoformans / drug effects
Microbial Sensitivity Tests

Substances

Antifungal Agents
Benzofurans