Carboxymethylated cyclosophoraose as a novel chiral additive for the stereoisomeric separation of some flavonoids by capillary electrophoresis

Yukyoung Jeon; Chanho Kwon; Eunae Cho; Seunho Jung

doi:10.1016/j.carres.2010.08.009

Carboxymethylated cyclosophoraose as a novel chiral additive for the stereoisomeric separation of some flavonoids by capillary electrophoresis

Carbohydr Res. 2010 Nov 2;345(16):2408-12. doi: 10.1016/j.carres.2010.08.009. Epub 2010 Aug 27.

Authors

Yukyoung Jeon¹, Chanho Kwon, Eunae Cho, Seunho Jung

Affiliation

¹ Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 1 Hwayang-dong Gwangjin-gu, Seoul 143-701, South Korea.

PMID: 20850110
DOI: 10.1016/j.carres.2010.08.009

Abstract

A carboxymethylated cyclosophoraose (CM-Cys) was synthesized by the chemical modification of neutral Cys, which was isolated from Rhizobium trifolii TA-1. CM-Cys was successfully applied as a novel chiral selector for the separation of some flavonoids including catechin, 3,5,7,3',4'-pentahydroxyflavanone, hesperidin, hesperetin, isosakuranetin, naringenin, naringin, and eriodictyol. The effects of pH, chiral additive concentration, and temperature on resolution and migration time were also studied.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Electrophoresis, Capillary
Flavonoids / isolation & purification*
Glucans / chemical synthesis
Glucans / chemistry*
Hydrogen-Ion Concentration
Molecular Structure
Stereoisomerism
Temperature

Substances

Flavonoids
Glucans
sophorose