The participation of cytochrome P450 3A4 in clozapine biotransformation is detected in people with schizophrenia by high-throughput in vivo phenotyping

J Clin Psychopharmacol. 2010 Oct;30(5):629-31. doi: 10.1097/JCP.0b013e3181f03e30.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biotransformation
  • Clozapine / metabolism*
  • Clozapine / therapeutic use
  • Cytochrome P-450 CYP3A / genetics*
  • Cytochrome P-450 CYP3A / physiology
  • High-Throughput Nucleotide Sequencing* / methods
  • Humans
  • Phenotype*
  • Prospective Studies
  • Schizophrenia / drug therapy
  • Schizophrenia / enzymology*
  • Schizophrenia / genetics*

Substances

  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Clozapine