Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro

Lu Zhao; Wei Li; Fengjuan Han; Lihui Hou; Jean-Patrice Baillargeon; Haixue Kuang; Yongyan Wang; Xiaoke Wu

doi:10.1016/j.fertnstert.2010.07.1090

Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro

Fertil Steril. 2011 Jan;95(1):461-3. doi: 10.1016/j.fertnstert.2010.07.1090. Epub 2010 Sep 16.

Authors

Lu Zhao¹, Wei Li, Fengjuan Han, Lihui Hou, Jean-Patrice Baillargeon, Haixue Kuang, Yongyan Wang, Xiaoke Wu

Affiliation

¹ Department of Obstetrics and Gynecology, First Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.

PMID: 20840879
DOI: 10.1016/j.fertnstert.2010.07.1090

Abstract

Theca cells with dexamethasone-induced insulin resistance showed defective glucose uptake and excessive testosterone production, both of which were effectively antagonized by berberine. Therefore, insulin-resistant theca cells may contribute to the pathogenesis of hyperandrogenism in polycystic ovary syndrome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Berberine / pharmacology*
Cells, Cultured
Dexamethasone / pharmacology*
Drug Interactions
Female
Glucocorticoids / pharmacology
Glucose / pharmacokinetics
Humans
Hyperandrogenism / metabolism*
In Vitro Techniques
Insulin Resistance*
Polycystic Ovary Syndrome / metabolism*
Theca Cells* / cytology
Theca Cells* / drug effects
Theca Cells* / metabolism

Substances

Glucocorticoids
Berberine
Dexamethasone
Glucose