Chemical constituents of Osyris alba and their antiparasitic activities

J Asian Nat Prod Res. 2010 Sep;12(9):814-20. doi: 10.1080/10286020.2010.502892.

Abstract

Phytochemical investigation of Osyris alba L. (Santalaceae) of Jordanian origin resulted in the isolation and identification of one new pyrrolizidine alkaloid, osyrisine (1), together with 16 other known compounds. The structures of all compounds were established on the basis of spectroscopic analysis. Osyrisine, catechin, and catechin-3-O-α-L-rhamnopyranoside exhibited a significant level of antiparasitic activity against two parasites, Entamoeba histolytica and Giardia intestinalis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiparasitic Agents / chemistry
  • Antiparasitic Agents / isolation & purification*
  • Antiparasitic Agents / pharmacology*
  • Catechin / chemistry
  • Chlorocebus aethiops
  • Entamoeba histolytica / drug effects*
  • Giardia lamblia / drug effects*
  • Jordan
  • Metronidazole / pharmacology
  • Molecular Structure
  • Parasitic Sensitivity Tests
  • Pyrrolizidine Alkaloids / chemistry
  • Pyrrolizidine Alkaloids / isolation & purification*
  • Pyrrolizidine Alkaloids / pharmacology*
  • Santalaceae / chemistry*
  • Stereoisomerism
  • Vero Cells

Substances

  • Antiparasitic Agents
  • Pyrrolizidine Alkaloids
  • osyrisine
  • Metronidazole
  • Catechin