Abstract
CRF01_AE is a major subtype of human immunodeficiency virus type 1 (HIV-1) circulating in Southeast Asia, including Thailand. We performed genotypic studies on HIV-1 CRF01_AE integrase derived from plasma samples from drug-naive Thai patients. Direct sequencing of amplified CRF01_AE integrase genes revealed that although no primary mutations associated with drug resistance to integrase inhibitors were detected, at least one secondary mutation was found in 96% of samples. Our results indicate that the impact of these mutations on the baseline drug susceptibility of CRF01_AE viruses to integrase inhibitors may need to be addressed prior to the introduction of these drugs in Southeast Asian countries, including Thailand.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / pharmacology*
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Drug Resistance, Viral*
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HIV Infections / virology*
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HIV Integrase / genetics*
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HIV-1 / drug effects*
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HIV-1 / genetics*
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HIV-1 / isolation & purification
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Humans
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Molecular Sequence Data
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Mutation, Missense*
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Plasma / virology
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RNA, Viral / genetics
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Sequence Analysis, DNA
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Thailand
Substances
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Anti-HIV Agents
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RNA, Viral
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HIV Integrase
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p31 integrase protein, Human immunodeficiency virus 1
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GENBANK/HM150808
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