Isoquinoline-based chiral monodentate N-heterocyclic carbenes

Chem Commun (Camb). 2010 Oct 28;46(40):7525-7. doi: 10.1039/c0cc02211j. Epub 2010 Sep 13.

Abstract

C(1)-symmetric isoquinoline-based chiral diaminocarbene ligands (MIQ) have been developed to block three quadrants of the metal coordination sphere, complementing C(2)-symmetric biisoquinoline-based ligands (BIQ). MIQ-Cu complexes catalyzed conjugate borylation of various α,β-unsaturated amides in good yields (82-99%) and enantioselectivities (75-87% ee).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amides / chemistry
  • Catalysis
  • Heterocyclic Compounds / chemistry
  • Isoquinolines / chemistry*
  • Ligands
  • Methane / analogs & derivatives*
  • Methane / chemistry
  • Models, Molecular
  • Molecular Structure
  • Stereoisomerism

Substances

  • Amides
  • Heterocyclic Compounds
  • Isoquinolines
  • Ligands
  • carbene
  • isoquinoline
  • Methane