Flavin-cyclodextrin conjugates as catalysts of enantioselective sulfoxidations with hydrogen peroxide in aqueous media

Chem Commun (Camb). 2010 Oct 28;46(40):7599-601. doi: 10.1039/c0cc02562c. Epub 2010 Sep 10.

Abstract

β-Cyclodextrin-flavin conjugates are highly efficient catalysts for the sulfoxidation of methyl phenyl sulfides with hydrogen peroxide in neat aqueous media operating at loadings down to 0.2 mol% and allowing for enantioselectivities up to 80% ee.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Flavins / chemistry*
  • Hydrogen Peroxide / chemistry*
  • Oxidation-Reduction
  • Stereoisomerism
  • Sulfides / chemistry*
  • Water / chemistry
  • beta-Cyclodextrins / chemistry*

Substances

  • Flavins
  • Sulfides
  • beta-Cyclodextrins
  • Water
  • methylphenylsulfide
  • Hydrogen Peroxide
  • betadex