Angiopoietins, abdominal aortic aneurysm and atherosclerosis

Atherosclerosis. 2011 Feb;214(2):237-43. doi: 10.1016/j.atherosclerosis.2010.08.051. Epub 2010 Aug 19.

Abstract

Abdominal aortic aneurysm (AAA) and atherosclerosis are common causes of mortality and morbidity in an aging population. Angiogenesis is believed to contribute to the development and progression of these diseases. Angiopoietins (angpts) are known to be important regulators of angiogenesis. Angpts can also influence inflammation and have been shown to possess both pro-atherosclerotic and atheroprotective effects. This review explores the potential roles that the angpts play in the development and progression of AAA and atherosclerosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiopoietins / metabolism*
  • Animals
  • Aortic Aneurysm, Abdominal / metabolism*
  • Aortic Aneurysm, Abdominal / pathology
  • Aortic Aneurysm, Abdominal / physiopathology
  • Atherosclerosis / metabolism*
  • Atherosclerosis / pathology
  • Atherosclerosis / physiopathology
  • Disease Progression
  • Humans
  • Inflammation Mediators / metabolism
  • Neovascularization, Pathologic / metabolism*
  • Neovascularization, Pathologic / physiopathology
  • Signal Transduction

Substances

  • Angiopoietins
  • Inflammation Mediators