The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics

Microbes Infect. 2010 Dec;12(14-15):1144-52. doi: 10.1016/j.micinf.2010.08.012. Epub 2010 Sep 9.

Abstract

Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an oncolytic agent in humans.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunologic Factors / metabolism*
  • Immunologic Factors / therapeutic use
  • Immunotherapy / methods
  • Myxoma virus / immunology*
  • Oncolytic Viruses / immunology*
  • Rabbits
  • Viral Proteins / metabolism*
  • Viral Proteins / therapeutic use

Substances

  • Immunologic Factors
  • Viral Proteins