NIR-enhanced drug release from porous Au/SiO2 nanoparticles

Chem Commun (Camb). 2010 Oct 28;46(40):7513-5. doi: 10.1039/c0cc01897j. Epub 2010 Sep 9.

Abstract

The ability of core/shell SiO(2)/Au nanoparticles (NPs) to heat upon being exposed to near-infrared (NIR) radiation is well known. In this work we have modified the synthesis procedure to obtain a mesoporous SiO(2) core and a porous Au shell that allows drugs to be loaded within the core porous space. The release of a model drug (ibuprofen) upon NIR activation is demonstrated.

MeSH terms

  • Delayed-Action Preparations / chemistry*
  • Gold / chemistry*
  • Ibuprofen / administration & dosage*
  • Infrared Rays
  • Lasers
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Porosity
  • Silicon Dioxide / chemistry*

Substances

  • Delayed-Action Preparations
  • Gold
  • Silicon Dioxide
  • Ibuprofen